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Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body
Author(s) -
Bourne Michael W.,
Margerun Larry,
Hylton Nola,
Campion Brian,
Lai JanJi,
Derugin Nikita,
Higgins Charles B.
Publication year - 1996
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880060209
Subject(s) - gadolinium , medicine , magnetic resonance angiography , coronal plane , nuclear medicine , magnetic resonance imaging , radiology , mediastinum , abdomen , contrast (vision) , chemistry , organic chemistry , artificial intelligence , computer science
Abstract The aims of this preliminary study were to establish the efficacy and minimum effective dose of TG 5 (FdDO3A) 52 gadolinium dendrimer for contrast‐enhanced, three‐dimensional (3D) time of flight (TOF) magnetic resonance angiography (MRA) of the body. In a dose ranging study in eight rabbits (Group A), each of two animals received 0.03; 0.02; 0.01; or 0.005 mmol/kg of the agent for 3D‐TOF MRA of the pelvic circulation in the axial and coronal planes. An additional nine animals (Group B) received a dose of 0.02 mmol/kg for 3D‐TOF MRA of the mediastinum, abdomen or of the lower limbs. Quantitative and qualitative analyses of the images from Group A demonstrated a dose‐related reduction in saturation effects and improved visualization of vascular structures, with maximal augmentation of the contrast‐to‐noise ratio (CNR) at 0.03 mmol/kg. The dose of 0.02 mmol/kg was found to be the minimal effective dose at the three vascular regions.