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Pulsed magnetization transfer contrast for MR imaging with application to breast
Author(s) -
Santyr Giles E.,
Kelcz Frederick,
Schneider Erika
Publication year - 1996
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880060136
Subject(s) - magnetization transfer , nuclear magnetic resonance , materials science , relaxation (psychology) , nuclear medicine , magnetization , biomedical engineering , magnetic resonance imaging , medicine , radiology , physics , magnetic field , quantum mechanics
The relative populations and transverse relaxation times of the solid‐like hydrogen pool (P B and T 2B ) and the magnetization transfer (MT) rates between the solid‐like and liquid‐like hydrogen pools (K) have been determined for three different agar gel concentrations (2%, 4%, and 8% by weight) as well as excised fibroglandular breast tissue specimens. P B was determined to be .003(.001), .01(.002), .02(.01), and .06(.01); T 2B was determined to be 13.0(.2), 14.0(.1), 14.5(.1) and 15.2(1.3) μs; and K was determined to be 0.78(.01), 1.15(.02), 2.00(.02), and 3.55(1.5) sec −1 for the 2%, 4%, and 8% agar gels and the fibroglandular tissue, respectively. The image signal intensities of a pulsed MTC‐prepared gradient‐echo imaging technique are predicted using these MT parameters and are shown to agree well with experimental data obtained from a clinical MR imaging system. This technique is shown to suppress signal intensity of fibroglandular breast tissue by 40%–50% without exceeding SAR limits (≤ 8W/kg) and is helpful for visualizing lesions and silicone implants.