Premium
Dynamic contrast‐enhanced MR imaging evaluation of osteosarcoma response to neoadjuvant chemotherapy
Author(s) -
Reddick Wilburn E.,
Bhargava Ravi,
Taylor June S.,
Meyer William H.,
Fletcher Barry D.
Publication year - 1995
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880050612
Subject(s) - medicine , osteosarcoma , chemotherapy , neoadjuvant therapy , radiology , magnetic resonance imaging , dynamic contrast , nuclear medicine , pathology , surgery , cancer , breast cancer
Assessment of osteosarcoma response to neoadjuvant chemotherapy has prognostic implications, but conventional imaging techniques have been unable to provide an accurate quantitative measure of tumor response. We developed an analysis of dynamic contrast‐enhanced MR imaging (DEMRI) to render an image of dynamic vector magnitudes (DVM) and to summarize the result in a quantitative parameter, mean DVM for the lesion (μ DVM ). We compared the (μ DVM from the examination before surgery with histologic results from an en bloc resection of the tumor in 19 cases. The final μ DVM value provided an accurate (89.5%) measure of tumor necrosis in osteosarcoma. Further, we analyzed the findings in 17 patients with osteosarcoma who completed three DEMRI examinations during the course of therapy. Tumors with higher μ DVM values at presentation had greater decreases in the parameter over the course of therapy. These results are consistent with the distribution of DVM values in these lesions serving as an indicator of tumor perfusion and a possible surrogate variable for drug delivery.