Premium
Csf‐suppressed t2‐weighted threel‐dimensional mp‐rage MR imaging
Author(s) -
Epstein Frederick H.,
Mugler John P.,
Cail Wayne S.,
Brookeman James R.
Publication year - 1995
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880050417
Subject(s) - fluid attenuated inversion recovery , t2 weighted , medicine , multiple sclerosis , pulse sequence , magnetic resonance imaging , fast spin echo , nuclear medicine , nuclear magnetic resonance , radiology , physics , psychiatry
Fluid‐attenuated inversion recovery (FLAIR) is a pulse sequence used for acquiring T2‐weighted images of the brain and spine in which the normally high signal intensity of CSF is greatly attenuated. The CSF‐sup pressed T2‐weighted contrast of this technique may be more sensitive to a variety of disorders than that of conventional Tz‐weighted imaging. The primary disadvantage associated with conventional spin‐echo implementations of FLAIR is the relatively limited anatomic coverage that can be achieved in a reasonable imaging time. We developed and optimized a three‐dimensional magnetization‐prepared rapid gradient‐echo (3D MP‐RAGE) pulse sequence that combines CSF‐suppressed T2‐weighted contrast similar to exleting FLAIR techniques with anatomic coverage characteristic of 3D imaging. A preliminary evaluation of the new sequence was performed by imaging healthy volunteers and patients with multiple sclerosis.