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Safety and optimum concentration of a manganese chloride–based oral MR contrast agent
Author(s) -
Bernardino Michael E.,
Weinreb Jeffrey C.,
Mitchell Donald G.,
Small William C.,
Morris Marie
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040620
Subject(s) - medicine , contrast (vision) , magnetic resonance imaging , manganese , nuclear medicine , image quality , adverse effect , radiology , chemistry , computer science , image (mathematics) , artificial intelligence , organic chemistry
To determine the safety of a manganese chloride‐based oral magnetic resonance (MR) contrast agent and the ideal concentration of the agent for marking in three different anatomic sites (stomach, middle of the small bowel, and ileocecal region), six healthy volunteers were evaluated before and after administration of 900 mL of three different concentrations of the contrast agent. Images were evaluated subjectively and objectively. No adverse events were noted. There was a minimal rise in manganese blood levels at 6 hours after administration, with a return to baseline at 24 hours. The imaging data demonstrated good‐to‐excellent bowel marking on T1‐weighted images at all three concentrations. However, on T2‐weighted images, the 40 mg Mn +2 /L concentration provided improved hypointense bowel marking relative to the 20 mg/L concentration. Little difference was seen between the 40 and 60 mg/L concentrations. Fast T1‐and T2‐weighted sequences provided superior image quality to that of conventional spin‐echo sequences.