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In vivo fluorine‐19 MR imaging: Relaxation enhancement with Gd‐DTPA
Author(s) -
Lee Haakil,
Price Ronald R.,
Holburn George E.,
Partain C. Leon,
Adams Max D.,
Cacheris William P.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040416
Subject(s) - gadolinium , magnetic resonance imaging , in vivo , nuclear magnetic resonance , fluorine , spin echo , relaxation (psychology) , nuclear medicine , t2 relaxation , signal (programming language) , chemistry , medicine , radiology , physics , computer science , microbiology and biotechnology , organic chemistry , biology , programming language
The lack of a naturally occurring background signal from fluorine in magnetic resonance (MR) imaging makes fluorinated compounds potentially attractive candidates for tissue‐specific MR contrast agents. Problems associated with the in vivo use of fluorinated compounds are toxicity, which limits the amount of agent that can be used; multiple resonance lines; and an excessively long T1, which leads to long sequence TRs and consequently long imaging times. Many fluorinated agents also possess complex MR spectra that result in chemical shift artifacts if not corrected. The authors demonstrate the use of an extracellular fluorinated agent with a single MR peak for selective imaging of a brain abscess in an animal model and show that the image signal per unit of acquisition time can be enhanced through the use of a T1 relaxation agent, gadolinium diethylenetriamine‐pentaacetic acid (DTPA). Trifluoromethylsulfonate was administered at a fluorine‐19 dose of 4 mmol/kg, and fluorine images of the induced abscess were acquired before and after the injection of a standard dose of Gd‐DTPA (0.1 mmol/kg); non—section‐selected projection images were used. Typical imaging times were less than 5 minutes. The signal enhancement factor achieved was approximately four (4.0 ± 0.8) with use of a 500/12 (TR msec/TE msec) spinecho sequence.