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Oxygen tension mapping with F‐19 echo‐planar MR imaging of sequestered perfluorocarbon
Author(s) -
Barker Bruce R.,
Mason Ralph P.,
Bansal Navin,
Peshock Ronald M.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040414
Subject(s) - oxygen tension , echo planar imaging , echo (communications protocol) , nuclear magnetic resonance , oxygen , arterial oxygen tension , medicine , nuclear medicine , magnetic resonance imaging , radiology , chemistry , computer science , physics , organic chemistry , computer network
The authors used fluorine‐19 inversion‐recovery (IR) echo‐planar imaging (EPI) to map oxygen tension on the basis of the spin‐lattice relaxation rate (R1) of sequestered perfluorocarbon. R1 measured with IR‐EPI varied as a linear function of oxygen tension and temperature, and the relationship agreed well with earlier spectroscopic findings. Oxygen tension maps of a mouse that had received a dose of perflubron emulsion were acquired before, during, and after the mouse breathed pure oxygen. Results showed low liver oxygen tension during air breathing, which increased during breathing of pure oxygen, with distinct regional heterogeneity, to 8–17%atm (60–130 torr [8.0–17.3 kPa]).