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Influence of in vivo copper on MR images of the liver in rats
Author(s) -
Nakakoshi Tsunenori,
Fujita Nobuyuki,
JongHon Kan,
Takeichi Noritoshi,
Miyasaka Kazuo
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040408
Subject(s) - in vivo , copper , pathology , radiology , medicine , materials science , biology , metallurgy , microbiology and biotechnology
To investigate the effects of in vivo copper on magnetic resonance (MR) images, the authors studied Long‐Evans cinnamon rats, which develop hepatitis and hepatocellular carcinoma as a result of abnormal copper metabolism. The livers of the rats were imaged before hepatitis developed; the absence of hepatic disease was confirmed histopathologically. The copper that accumulated in the liver of the rats was thought to exist in the form of divalent ions, which were suspected of reducing the T1 and T2 of neighboring protons. However, the signal intensities of the liver on T1‐ and T2*‐weighted images did not change, suggesting that in vivo copper, even when accumulated abnormally, does not influence the signal intensity of MR images.