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Short TE hydrogen‐1 spectroscopic MR imaging of normal human brain: Reproducibility studies
Author(s) -
Jackson Edward F.,
Doyle Timothy J.,
Wolinsky Jerry S.,
Narayana Ponnada A.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040406
Subject(s) - reproducibility , creatine , phosphocreatine , nuclear medicine , nuclear magnetic resonance , magnetic resonance imaging , choline , apodization , medicine , chemistry , radiology , physics , optics , chromatography , energy metabolism
Abstract Studies have been performed to evaluate the reproducibility of longitudinal acquisitions with short TE spectroscopic magnetic resonance (MR) imaging of human brain. In healthy volunteers, the ratios of N ‐acetyl‐aspartate (NAA) and choline (Cho) with respect to total creatine (Cr) (creatine and phosphocreatine) have been examined in terms of voxel‐to‐voxel, acquisition‐to‐acquisition, and subject‐to‐subject variation. Overall coefficients of variation for NAA/Cr ratios and Cho/Cr ratios were 18% and 16%, respectively. The interacquisition variation was not statistically significant ( P = .05) for either ratio. In terms of F ratios, the dominant source of variation in the NAA/Cr ratio was intersubject variability, whereas for the Cho/Cr ratio the dominant source of variation was intervoxel variability. Consequences of spectroscopic processing with spatial apodization and postacquisition water suppression and resolution enhancement were also examined. Such reproducibility studies are crucial if longitudinal spectroscopic evaluations are to be performed in a clinical setting to follow the natural course of disease states or the effects of therapy.