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Repeat cerebral blood volume assessment with first‐pass MR imaging
Author(s) -
Runge Val M.,
Kirsch John E.,
Wells John W.,
Dunworth John N.,
Hilaire Luna,
Woolfolk Cecil E.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040335
Subject(s) - medicine , nuclear medicine , steady state free precession imaging , magnetic resonance imaging , middle cerebral artery , first pass , bolus (digestion) , white matter , occlusion , radiology , ischemia , cardiology , arithmetic , mathematics
The feasibility of performing multiple first‐pass studies with dynamic, contrast material‐enhanced magnetic resonance (MR) imaging was evaluated in a cat model of acute middle cerebral artery (MCA) ischemia. Two dynamic series of SSFP (steady‐state free precession) images were acquired in each animal ( n = 5) with a conventional 1.5‐T imager. The initial first‐pass study was acquired at 60 minutes after MCA occlusion, and the second study at 70 minutes, with each performed during an intravenous bolus injection of a 0.5 mmol/kg dose of gadoteridol. In both first‐pass studies, differentiation of normal and ischemic gray and white matter was highly statistically significant. At a threshold of P <.01, no statistically significant difference in the peak signal intensity between the first and second studies was noted. A difference between the two studies in the recovery to baseline was seen, presumably due to T1 effects. First‐pass MR studies can be repeated within the time frame of a single clinical examination, expanding their utility.