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Ischemic heart disease: Assessment with gadolinium‐enhanced ultrafast MR imaging and dipyridamole stress
Author(s) -
Eichenberger André C.,
Schuiki Ernst,
Köhli Victor D.,
Amann F. Wolfgang,
McKin Graeme C.,
von Schulthess Gustav K.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040331
Subject(s) - dipyridamole , medicine , coronary artery disease , thallium , magnetic resonance imaging , gadolinium , scintigraphy , ischemia , perfusion scanning , myocardial perfusion imaging , perfusion , cardiology , radiology , bolus (digestion) , nuclear medicine , inorganic chemistry , chemistry , materials science , metallurgy
The potential of magnetic resonance (MR) imaging for the detection of myocardial perfusion abnormalities in patients with coronary artery disease has not been fully explored. A feasibility study was conducted in 10 patients with a novel approach to determine whether myocardial ischemia can be assessed with MR imaging and dynamic first‐pass bolus tracking enhanced with gadolinium tetraazacyclododecanetetraacetic acid (DOTA). Three tomographic planes were acquired before and after pharmacologic stress with dipyridamole, with use of the bolus‐tracking series at rest as a reference. The change in myocardial rate of enhancement was compared with the results obtained by means of the established methods, exercise thallium scintigraphy and coronary angiography. Detection of ischemic regions with MR imaging showed a sensitivity, specificity, and diagnostic accuracy of 65%, 76%, and 74%, respectively. Ultrafast MR imaging can be used to detect regions of myocardial ischemia.