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Prolonged positive contrast enhancement with Gd‐EOB‐DTPA in experimental liver tumors: Potential value in tissue characterization
Author(s) -
Ni Yicheng,
Marchal Guy,
Yu Jie,
Mühler Andreas,
Lukito Gregorius,
Baert Albert L.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040322
Subject(s) - hccs , gadolinium , magnetic resonance imaging , hepatocellular carcinoma , infiltration (hvac) , medicine , nuclear medicine , pathology , chemistry , radiology , materials science , organic chemistry , composite material
To evaluate the potential of the hepatobiliary magnetic resonance (MR) imaging contrast agent gadolinium EOB‐DTPA (ethoxybenzyl diethylenetria‐minepentaacetic acid) for the characterization of hepatic tumors, 79 primary and six implanted hepatomas in 38 rats were studied. MR imaging findings after administration of Gd‐DTPA (0.3 mmol/kg) and Gd‐EOB‐DTPA (30 μmol/kg) were correlated with microangiographic and histologic findings. Gd‐EOB‐DTPA produced a strong liver enhancement, which caused prompt negative contrast enhancement (CE) in all implanted hepatomas and in 77 of 79 primary hepatomas. A positive CE that lasted up to 2 hours was found in two of 79 primary hepatomas, both of which were highly differentiated (grade I) hepatocellular carcinomas (HCCs). The rest were moderately differentiated to undifferentiated HCCs (grades II‐IV). Rim enhancement, which corresponded histologically to peritumoral malignant infiltration sequestering normal hepatocytes, was seen around all implanted and some primary hepatomas. Positive tumor CE after administration of Gd‐EOB‐DTPA in this study is much less frequent but much more specific in comparison with the results of previous studies with manganese‐DPDP (N, N′‐dipyridoxylethylenediamine‐N,N′‐diacetate 5,5′‐bis[phosphate]). These findings may help further discriminate hepatic tumors.