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Gadoteridol dose dependence in MR imaging of a liver abscess model
Author(s) -
Runge Val M.,
Kirsch John E.,
Woolfolk Cecil,
Brack Mitchell A.,
Garneau Robert A.
Publication year - 1994
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880040320
Subject(s) - medicine , magnetic resonance imaging , lesion , nuclear medicine , abscess , liver abscess , radiology , pathology , surgery
Abstract A necrotic liver abscess model was studied with magnetic resonance (MR) imaging at 1.5 T before and after intravenous administration of gadoteridol at doses of 0.1, 0.25, and 0.5 mmol/kg in 24 rabbits. Enhancement characteristics and lesion delineation were assessed with both breath‐hold and non‐breath‐hold imaging techniques. Lesion delineation, as assessed both by signal intensity measurements and evaluations by two image readers blinded to imaging technique, was greatest on high‐dose (0.5 mmol/kg) breath‐hold images. Lesion rim enhancement was seen consistently only on postcontrast images obtained at a dose of 0.5 mmol/kg and progressed with time after injection of contrast material.