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Perfusion and diffusion MR imaging of thromboembolic stroke
Author(s) -
de Crespigny Alexander J.,
Tsuura Mitsuharu,
Moseley Michael E.,
Kucharczyk John
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030510
Subject(s) - perfusion , magnetic resonance imaging , medicine , perfusion scanning , stroke (engine) , effective diffusion coefficient , ischemia , nuclear medicine , cardiology , radiology , mechanical engineering , engineering
A carotid embolic stroke model in rats was studied with a combination of diffusion‐ and perfusion‐sensitive magnetic resonance (MR) imaging at 4.7 T. Capillary blood deoxygenation changes were monitored during formation of focal ischemia by acquiring multisection magnetic susceptibility‐weighted echo‐planar images. A signal intensity decrease of 7% ± 3 in ischemic brain (1% ± 2 in normal brain) was attributable to a T2* decrease due to increased blood deoxygenation, which correlated well with subsequently measured decreases in the apparent diffusion coefficient. The same multisection methods were used to track the first‐pass transit of a bolus of dysprosium‐DTPA‐BMA [diethylenetriaminepentaacetic acid‐bis(methylam‐ide)] to assess relative tissue perfusion before and after stroke and after treatment with a thrombolytic agent. Analysis of contrast agent transit profiles suggested a total perfusion deficit in ischemic tissue and essentially unchanged perfusion in normal brain tissue after stroke.