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Fatty replacement of bone marrow after radiation therapy for Hodgkin disease: Quantification with chemical shift imaging
Author(s) -
Kauczor HansUlrich,
Dietl Barbara,
Brix Gunnar,
Jarosch Klaus,
Knopp Michael V.,
Van Kaick Gerhard
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030405
Subject(s) - bone marrow , medicine , magnetic resonance imaging , radiation therapy , nuclear medicine , radiology , pathology
The authors studied the long‐term fatty replacement of bone marrow in 23 patients who had received radiation therapy for Hodgkin disease, with T1‐weighted magnetic resonance imaging and quantitative chemical shift imaging. T1‐weighted images revealed a mostly homogeneous high‐signal‐intensity pattern, in contrast to the hypointense pattern of nonirradiated marrow. The degree of fatty replacement was objectively assessed with chemical shift imaging, comparing patients to age‐matched healthy volunteers. The authors found an increase in relative fat signal of 37% in the thoracic spine and 34% in the lumbar spine. The relative fat signal of nonirradiated pelvic and femoral marrow was decreased by 8%, indicating marrow reconversion. No radiation dose dependence was found in the range from 25 to 50 Gy. No signs of marrow regeneration were observed 15‐126 months after radiation therapy. With chemical shift imaging, the degree of long‐term radiogenic fatty replacement of the bone marrow can be quantified, confirming the lack of regeneration after radiation therapy for Hodgkin disease.