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Hydrogen‐1, sodium‐23, and carbon‐13 MR spectroscopy of cartilage degradation in vitro
Author(s) -
Jelicks Linda A.,
Paul Pradip K.,
O'Byrne Elizabeth,
Gupta Raj K.
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030403
Subject(s) - cartilage , nuclear magnetic resonance , chemistry , spectroscopy , sodium , magnetic resonance imaging , in vitro , papain , proteoglycan , relaxation (psychology) , pathology , medicine , biochemistry , anatomy , radiology , enzyme , physics , organic chemistry , quantum mechanics
Viable bovine nasal cartilage was examined with magnetic resonance (MR) spectroscopy. Digestion of the proteoglycan matrix by papain or trypsin was accompanied by substantial changes in carbon‐13, sodium‐23, and hydrogen‐1 MR spectra and relaxation parameters, with C‐13 MR spectra showing the most pronounced changes. These results indicate the potential of MR spectroscopy (and imaging) for noninvasive evaluation of cartilage disease and monitoring of patients with degenerative joint diseases.