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Rapid MR imaging of a vascular challenge to focal ischemia in cat brain
Author(s) -
De Crespigny Alexander J.,
Wendland Michael F.,
Derugin Nikita,
Vexler Zinaida S.,
Moseley Michael E.
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030308
Subject(s) - ischemia , magnetic resonance imaging , medicine , bolus (digestion) , oxygenation , radiology , cardiology , anesthesia
Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2 T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*‐weighted (gradient‐recalled) echo‐planar MR imaging. Signal loss in the T2*‐weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion‐weighted and contrast agent bolus–‐tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism.