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Characterization of atherosclerosis with a 1.5‐T imaging system
Author(s) -
Gold Garry E.,
Pauly John M.,
Glover Gary H.,
Moretto John C.,
Macovski Albert,
Herfkens Robert J.
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030216
Subject(s) - hemosiderin , calcification , ex vivo , magnetic resonance imaging , aorta , pathology , agarose , anatomy , medicine , materials science , in vivo , biology , radiology , microbiology and biotechnology , cardiology , biochemistry
It is shown that a conventional 1.5‐T magnetic resonance (MR) imaging system can help characterize some of the key components of atherosclerotic plaque ex vivo. Fresh human aorta with atheromata was suspended in solutions of agarose and manganese chloride and heated to body temperature. The specimens were imaged with modified Dixon and projection‐reconstruction imaging sequences. The specimens were then examined histologically to obtain direct correlation between images, spectra, and histologic characteristics. The results show that vessel wall and plaque components can be identified by means of their MR characteristics and correlated with their histologic appearance. The authors were able to identify normal vessel wall components, such as adventitial lipids and smooth muscle. They were also able to identify and localize plaque components such as fibrous tissue, calcification, lipids, and possible areas of hemorrhage and hemosiderin deposition.