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Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo
Author(s) -
Rubin Daniel L,
Muller Holde H.,
Sidhu Manrita K.,
Young Stuart W.,
Hunke William A.,
Gorman William G.
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030119
Subject(s) - in vivo , contrast (vision) , magnetic resonance imaging , magnetic nanoparticles , nuclear magnetic resonance , materials science , medicine , biomedical engineering , radiology , nanotechnology , nanoparticle , physics , optics , biology , microbiology and biotechnology
Abstract Recent in vitro studies suggested there is an optimal range of concentration and viscosity for a liquid formulation of oral magnetic particles (WIN 39996) for magnetic resonance (MR) imaging of the gastrointestinal (GI) tract. To determine whether this formulation is also effective in vivo and whether differing viscosity and administration regimen affect GI distribution of the contrast agent, a range of concentrations of iron (75, 150,and 200 μg/mL) and viscosities (1, 150, and 600 cp) were imaged in dogs at 1.5 T with conventional spin‐echo and fat‐saturation pulse sequences. The effects of dose regimen (single vs divided dose) and subject position (supine vs right lateral decubitus) were also studied. The 75 and 200 μg/mL concentrations were unacceptable for MR imaging, while 150 μ.g/mL was effective. The GI distribution of the contrast agent was affected jointly by viscosity, subject position, and dose regimen. The 150 μg/mL formulation produced excellent GI contrast enhancement in vivo for both 150‐ and 600‐cp viscosities. The choice of optimal viscosity may depend on the preferred administration regimen.