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First‐pass evaluation of renal perfusion with turboflash MR imaging and superparamagnetic iron oxide particles
Author(s) -
Trillaud Hervë,
Grenier Nicolas,
Degreze Philippe,
Louail Catherine,
Chambon Catherine,
Franconi JeanMichel
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030115
Subject(s) - medulla , renal cortex , magnetic resonance imaging , perfusion , nuclear medicine , subtraction , medicine , intensity (physics) , renal medulla , renal artery , nuclear magnetic resonance , reproducibility , flip angle , kidney , radiology , chemistry , anatomy , physics , arithmetic , mathematics , quantum mechanics , chromatography
First‐pass intrarenal hemodynamics were studied with superparamagnetic iron oxide particles and a T2‐weighted TurboFLASH (fast low‐angle shot) magnetic resonance (MR) imaging sequence. Four groups of five rabbits each were imaged after bolus injection of 40, 100, 140, and 200 μ,mol/kg iron, respectively. Images were acquired every 1.2 seconds, with an acquisition time of 700 msec. The signal intensity was measured in the cortex, outer medulla, inner medulla, and globally. In preliminary pathologic applications, two rabbits were imaged after ligation of the lumbar ureter and two after embolization of the renal artery. The reproducibil‐ity of the normal dynamics was evaluated with a cross‐correlation test. On the images, the intravas‐cular progression of the iron particles could be visualized within the cortex and the two compartments of the medulla in all cases. The maximal reduction in signal intensity in the cortex and medulla increased with the dose. The relationship between signal intensity decrease and dose was not linear, and the reproducibility of the signal intensity versus time plots was acceptable only at the 140 and 200 μ.mol/kg doses. The decrease in signal intensity was reduced and delayed in the emboli‐zed and hydronephrotic kidneys.