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Mn‐DPDP enhancement patterns of hepatocellular lesions on MR images
Author(s) -
Vogl Thomas J.,
Hamm Bernd,
Schnell Birgit,
McMahon Christine,
Branding Gordian,
Lissner Josef,
Wolf KarlJürgen
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030110
Subject(s) - focal nodular hyperplasia , medicine , magnetic resonance imaging , hepatocellular carcinoma , nuclear medicine , hyperplasia , gradient echo , pathology , spin echo , radiology
The recently developed paramagnetic hepatobiliary contrast agent manganese dipyridoxyl diphosphate (DPDP) was evaluated in eight patients. Pathologic diagnoses included five hepatocellular carcinomas, two cirrhoses, and one focal nodular hyperplasia. T1‐weighted spin‐echo and gradient‐echo images were obtained after intravenous injection of 5 or 10 μmol/kg Mn‐DPDP; these were compared with un‐enhanced T1‐weighted spin‐echo and gradient‐echo images and T2‐weighted spin‐echo images. In all patients with lesions of hepatocellular origin, focal areas of increased enhancement were seen in the lesions after administration of Mn‐DPDP. In the cir‐rhotic livers, these areas corresponded to foci of hepatic regeneration. In all patients, the signal‐to‐noise ratio in normal liver tissue increased significantly after injection of Mn‐DPDP. Signal intensity in the six primary liver tumors was further increased, so that they appeared hyperintense relative to surrounding liver tissue on all T1‐weighted images. Conspicuity and demarcation of all lesions were improved on Mn‐DPDP‐enhanced images.