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In vivo relaxometry of three brain tumors in the rat: Effect of Mn‐TPPS, a tumor‐selective contrast agent
Author(s) -
Wilmes Lisa J.,
HoehnBerlage Mathias,
Els Thomas,
Bockhorst Kurt,
Eis Manfred,
Bonnekoh Petra,
Hossmann KonstantinAlexander
Publication year - 1993
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880030103
Subject(s) - schwannoma , in vivo , relaxometry , brain tumor , glioma , contrast (vision) , pathology , medicine , neuroblastoma , chemistry , nuclear medicine , magnetic resonance imaging , radiology , cancer research , spin echo , biology , cell culture , genetics , microbiology and biotechnology , artificial intelligence , computer science
T1 and T2 were determined simultaneously in vivo at 4.7 T in implanted rat brain tumors. Three different tumor cell lines were implanted in the right caudate nucleus: the F98 glioma, the E367 neuro‐blastoma, and the RN6 schwannoma. Their T1 and T2 values (mean ± standard deviation [msec]), respectively, were 1,312 ± 107 and 89 ± 3 (gli‐oma), 1,284 ± 86 and 87 ± 7 (neuroblastoma), and 1,338 ± 85 and 86 ± 9 (schwannoma). The T1 values (msec) of normal brain and muscle were 1,090 ± 59 and 1,139 ± 77, respectively, and the T2 values (msec) were 76 ± 3 and 36 ± 2, respectively. After injection of the contrast agent manganese (III) tet‐raphenylporphine sulfonate (TPPS) the T1 of all three tumors decreased by 30% and the T2 by 10%, whereas no such change in relaxivity was noted in normal brain. As a result, strong contrast enhancement of the three tumor types was seen on T1‐weighted images. The tumor was clearly delineated and correlated with findings at histologic examination. This tumor enhancement was followed up for 4 days with quantitative relaxation time measurements, and the strong, selective reduction in T1 for all three tumor types after Mn‐TPPS injection was preserved over the entire observation period.