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Ultrafast MR imaging of water mobility: Animal models of altered cerebral perfusion
Author(s) -
McKinstry Robert C.,
Weiskoff Robert M.,
Belliveau John W.,
Vevea James M.,
Moore John B.,
Kwong Kenneth W.,
Halpern Elkan F.,
Rosen Bruce R.
Publication year - 1992
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880020404
Subject(s) - intravoxel incoherent motion , nuclear magnetic resonance , magnetic resonance imaging , perfusion , white matter , hypercapnia , cerebral perfusion pressure , diffusion , effective diffusion coefficient , nuclear medicine , chemistry , medicine , physics , radiology , anatomy , respiratory system , thermodynamics
“Single shot” magnetic resonance (MR) diffusion imaging was used to study the details of signal decay curves in experimental perturbations of cerebral perfusion induced by hypercapnia or death. Despite large perfusion increases observed with dynamic susceptibility‐contrast MR imaging, no correlation with these changes was seen in either the diffusion coefficient or any other intravoxel incoherent motion (IVIM) model parameters in dog gray matter as arterial carbon dioxide pressure increased. Non‐monoexponential signal decay in cat gray matter was seen both before and after death. In addition, cat gray matter demonstrated a steady decrease in the diffusion coefficient after death. These data are strong evidence that the fast component of the non‐monoexponential diffusion‐related signal decay is not due solely to perfusion. The authors believe that a second compartment of nonex‐changing spins, most likely cerebrospinal fluid, accounts for the non‐monoexponential decay.