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Quantitation of total metastatic tumor volume in the rat liver: Correlation of MR and histologic measurements
Author(s) -
Mahmood Umar,
Devitt Mary L.,
Kocheril Paul G.,
SutantoWard Erika,
Ballon Douglas,
Sigurdson Elin R.,
Koutcher Jason A.
Publication year - 1992
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880020314
Subject(s) - magnetic resonance imaging , medicine , pathology , liver tumor , metastasis , nodule (geology) , metastatic tumor , chemotherapy , animal model , nuclear medicine , radiology , hepatocellular carcinoma , cancer , biology , paleontology
Assessing tumor response to chemotherapy in the liver has always been difficult. Most investigators estimate tumor volume as either a product of the two perpendicular diameters of a tumor nodule, or, in animal studies, simply count surface tumor nodules. The authors evaluated magnetic resonance (MR) imaging as a technique for determining absolute tumor volume in the liver in an animal model. Specifically, histologic volumetric and MR imaging measurements of tumor and liver volumes were quantitatively compared over a wide range of tumor burdens in a rat model of hepatic metastasis of a colorectal carcinoma. Twenty‐three rats were imaged, with two different section thicknesses used in each animal. Both section thicknesses showed highly significant correlations between MR and histologic measurements for both tumor and liver volumes (P <.001). MR imaging may be useful for noninvasively quantifying tumor burden and temporal response of metastatic disease in the liver to novel antineoplastic regimens.