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Change in red blood cell relaxation with hydration: Application to MR imaging of hemorrhage
Author(s) -
Taber Katherine H.,
Ford Joseph J.,
Jensen Ray S.,
Chin Hsiao Yang,
Udden Mark M.,
Plishker Gordon A.,
Contant Charles F.,
Hayman L. Anne
Publication year - 1992
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880020214
Subject(s) - medicine , red blood cell , radiology , nuclear magnetic resonance , physics
T1 and T2 were measured in unclotted blood samples with 0.24‐ and 4.7‐T spectrometers. The fraction by weight of intracellular water in the red blood cells (RBCs) was varied by either osmotic manipulation or density separation in concentrated (packed RBCs) and dilute (RBCs suspended in buffer or serum) samples. Reducing the cell water content caused a moderate decrease in T1 and a profound decrease in T2 at both 0.24 and 4.7 T. Conversely, increasing the cell water content caused an increase in both T1 and T2. The authors conclude that dehydrated RBCs in an area of hemorrhage would cause a substantial decrease in signal intensity on long TR/TE (T2‐weighted) images. Overhydration of RBCs would have the opposite effect.