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OMR, a positive bowel contrast agent for abdominal and pelvic MR imaging: Safety and imaging characteristics
Author(s) -
Patten Randall M.,
Moss Albert A.,
Fenton Theresa A.,
Elliott Sharon
Publication year - 1992
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880020105
Subject(s) - medicine , magnetic resonance imaging , pelvis , abdomen , artifact (error) , radiology , nuclear medicine , biology , neuroscience
To determine the safety and imaging characteristics of OMR — an effervescent solution of ferric ammonium citrate — as a bowel contrast agent, magnetic resonance (MR) imaging at 1.5 T was performed in 29 volunteers. T1‐ and T2‐weighted images of the upper abdomen and pelvis were obtained before and after oral administration of OMR at doses of 100–400 mg of iron in 300–600 mL of water. Respiratory‐ordered phase encoding and presaturation pulses were used routinely for artifact suppression. All dose levels of OMR provided marking of the bowel by increasing intraluminal signal intensity; however, the degree and percentage of small bowel opacification appeared more prominent at higher dose levels of iron. Semisolid or watery bowel movements were noted in 31% of subjects, but no clinically important laboratory abnormalities were seen. OMR improved delineation of the head of the pancreas on T1‐weighted images in 72% of subjects but was less useful in defining the body and tail. OMR is a safe and effective bowel contrast agent for MR imaging. Because artifacts due to movement of hyperintense bowel may degrade the images, OMR may be most useful on short TR/TE or fast imaging pulse sequences or when combined with antiperistaltic agents.