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Efficacy of nonionic low‐osmolar gadodiamide injection in animals with intracranial mass lesions
Author(s) -
Carvlin Mark J.,
Rajan S. Sunder,
Rosa Louis,
Muraki Alan S.,
Francisco John,
Rocklage Scott M.
Publication year - 1992
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880020104
Subject(s) - gadodiamide , medicine , magnetic resonance imaging , nuclear medicine , gadolinium , radiology , parenchyma , pathology , materials science , metallurgy
Gadodiamide injection is a nonionic, low‐osmo‐lar formulation of a paramagnetic metal chelate complex consisting of gadodiamide and caldia‐mide sodium. The efficacy of gadodiamide injection as a magnetic resonance (MR) imaging enhancement medium was evaluated by imaging intracranial 9L‐glioma lesions induced in rats and naturally occurring lesions in dogs. T1‐ and T2‐weighted spin‐echo images were obtained before and after administration of gadodiamide injection at doses of 0.1 and 0.2 mmol/kg. On the precontrast T1‐weighted images, the intracranial lesions were not well seen, appearing isoin‐tense to normal brain parenchyma. Although the presence of disease was shown unequivocally on the T2‐weighted images, the margins of the masses could not be delineated. Postcontrast T1‐weighted images were characterized by marked enhancement of the tumor, with no change in signal intensity in the surrounding edematous brain tissue. Gadodiamide injection was efficacious in identifying areas of blood‐brain barrier breakdown associated with intracranial masses.