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In vivo F‐19 chemical shift imaging with FTPA and antibody‐coupled FMIQ
Author(s) -
Mishima Hideyuki,
Kobayashi Tetsurou,
Shimizu Masahiro,
Tamaki Yasuhiro,
Baba Masashi,
Shimano Takashi,
Itoh Soichi,
Yamazaki Masaru,
Iriguchi Norio,
Takahashi Mutsumasa,
Mori Takesada
Publication year - 1991
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880010616
Subject(s) - carcinoembryonic antigen , in vivo , antibody , spleen , chemistry , pathology , medicine , cancer , biology , immunology , microbiology and biotechnology
A mixture of perfluoromethyldecahydroisoquinoline (FMIQ) emulsion coupled with anti‐CEA (carcinoembryonic antigen) antibody and perfluorotripropylamine (FTPA) was injected into a nude mouse inoculated with human colon carcinoma LS174T. Three days after the injection, in vivo fluorine‐19 chemical shift images of the spectral signals of the two perfluorocarbons (PFCs) were obtained simultaneously. The signal intensities and distributions of FMIQ and FTPA were similar in the liver and spleen but different in the tumor. FMIQ was detected in almost the entire tumor, with scattered areas of high uptake. FTPA, however, was detected only in the center of the tumor. The results suggest that F‐19 chemical shift imaging of two PFCs, one coupled to antibody and the other not, has potential application in tumor diagnosis.