Premium
MR imaging of normal rat brain at 0.35 T and correlated histology
Author(s) -
Fiel Robert J.,
Alletto James J.,
Severin Charles M.,
Nickerson Peter A.,
Acara Margaret A.,
Pentney Roberta J.
Publication year - 1991
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880010606
Subject(s) - white matter , magnetic resonance imaging , cerebrum , coronal plane , pathology , histology , subarachnoid space , cerebellum , medicine , cerebrospinal fluid , neuroimaging , grey matter , perivascular space , anatomy , radiology , central nervous system , psychiatry , endocrinology
A custom‐built small‐animal transceiver was used for in vivo imaging of normal rat brain at 0.35 T, with the objective of identifying anatomic components by comparison of images with corresponding histologic sections. The cerebrum, cerebellum, brain stem, ventricles, hippocampus, and subarachnoid space were identified and cerebrospinal fluid (CSF) was differentiated from gray matter and white matter on coronal and transaxial magnetic resonance (MR) images. These images compare favorably with those obtained by others at higher field strengths in regard to delineating major neuroanatomic structures. It is concluded that this technique will be useful for investigating smallanimal models of human neurologic disease involving morphologic and morphometric changes in gray matter, white matter, and CSF‐filled spaces.