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Use of magnetic particles for sensitizing MR images to blood flow
Author(s) -
Hardy Peter A.,
Bronskill Michael J.,
Belanger MarieJose,
Henkelman R. Mark
Publication year - 1991
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880010407
Subject(s) - intravoxel incoherent motion , nuclear magnetic resonance , magnetic resonance imaging , capillary action , blood flow , magnetic field , microcirculation , materials science , biomedical engineering , mechanics , physics , radiology , medicine , diffusion mri , composite material , quantum mechanics
Magnetic resonance (MR) images made with the IVIM (intravoxel incoherent motion) technique for demonstrating tissue microcirculation are limited in sensitivity because of the small volume of blood involved. This limitation may be overcome by incorporating magnetic particles into the flow. The magnetic perturbation caused by the particles extends beyond the walls of the capillary and affects a much larger volume than that of the flowing material. Imaging experiments conducted with an artificial capillary system for renal dialysis, containing large magnetic particles, showed that signal intensity decreased with increasing flow rate through the dialysis bundle and with increasing particle concentration. Predictions of the effect based on a theoretical model of spin dephasing in the field of a magnetic dipole agreed with the experimental data. The results hold promise for development of the technique in vivo.