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Direct hepatic tumor injection in rats: Can it be used for analysis of MR imaging contrast agents?
Author(s) -
Murphy Frederick B.,
del Pilar Fernandez Maria,
Kossoff Marjorie B.,
Dillehay Dirck L.,
Malko John A.,
Bernardino Michael E.
Publication year - 1991
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880010111
Subject(s) - magnetic resonance imaging , medicine , mri contrast agent , hepatic tumor , contrast (vision) , pathology , nuclear medicine , radiology , artificial intelligence , computer science
With a recently described rat model technique for direct hepatic injection of tumor cells for imaging research, there were concerns that the injection itself might produce lesions detectable with magnetic resonance (MR) imaging, thereby producing false‐positive results. To examine this possibility, the authors prospectively studied 14 Sprague‐Dawley rats after direct hepatic injection of cells from a rat hepatoma cell line. The rats were imaged with a variety of pulse sequences before and after intravenous injection of the contrast agent manganese dipyridoxal diphosphate at a dose of 8 μmol/kg. No intrahepatic lesions could be detected with MR imaging during the first 6 days after direct hepatic injection of the tumor cells. Therefore, the direct injection technique should be accurate for evaluating various MR imaging sequences and contrast agents for early hepatic tumor detection.