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Application of magnetic resonance to animal models of cerebral ischemia
Author(s) -
Hoehn Mathias,
Nicolay Klaas,
Franke Claudia,
van der Sanden Boudewijn
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1213
Subject(s) - magnetic resonance imaging , ischemia , animal model , stroke (engine) , neuroscience , functional magnetic resonance imaging , neuroimaging , medicine , nuclear magnetic resonance , biology , radiology , cardiology , physics , thermodynamics
The present review has been compiled to highlight the role of magnetic resonance imaging (MRI) and MR spectroscopy (MRS) for the investigation of cerebral ischemia in the animal experimental field of basic research. We have focused on stroke investigations analyzing the pathomechanisms of the disease evolution and on new advances in both nuclear MR (NMR) methodology or genetic engineering of transgenic animals for the study of complex molecular relationships and causes of the disease. Furthermore, we have tried to include metabolic and genetic aspects, as well as the application of functional imaging, for the investigation of the disturbance or restitution of functional brain activation under pathological conditions as relates to controlled animal experiments. J. Magn. Reson. Imaging 2001;14:491–509. © 2001 Wiley‐Liss, Inc.