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Magnetic resonance imaging of atherosclerotic plaques using superparamagnetic iron oxide particles
Author(s) -
Schmitz Stephan A.,
Taupitz Matthias,
Wagner Susanne,
Wolf KarlJürgen,
Beyersdorff Dirk,
Hamm Bernd
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1194
Subject(s) - medicine , magnetic resonance imaging , aorta , radiology , population , lymph node , arteriosclerosis , nuclear medicine , pathology , environmental health
Experimental data show accumulation of superparamagnetic iron oxide (SPIO) particles in atherosclerotic plaques. SPIO uptake occurred in plaques, suggesting an increased endothelial permeability and macrophage infiltrates as signs of inflammatory plaque activity. We incidentally observed SPIO uptake in aortic and arterial wall segments in patients who had originally received the magnetic resonance (MR) contrast agent for staging lymph node metastases. Twenty patients (19 male, 1 female; mean age, 64; range, 41–78 years) with bladder or prostate cancer underwent MR imaging (MRI) using a T2*‐weighted high‐resolution gradient‐echo sequence prior to and 24–36 hours after intravenous injection of 2.6 mg of Fe/kg of SPIO (Sinerem®). The aorta, both common external and internal iliac, as well as both superficial femoral arteries, were retrospectively analyzed for atherosclerotic wall changes. One patient was excluded. A positive finding was defined as an area of pronounced signal loss on postcontrast images clearly confined to the arterial wall, which was absent in the precontrast examination or increased in size. Such a finding was observed in one to three arteries in 7 of the 19 patients. The pronounced signal loss in the wall of the aorta and pelvic arteries seen in part of an elderly patient population after intravenous SPIO administration strongly suggests that this contrast agent accumulates in human atherosclerotic plaques. J. Magn. Reson. Imaging 2001;14:355–361. © 2001 Wiley‐Liss, Inc.