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Proton magnetic resonance spectroscopy of choroid plexus tumors in children
Author(s) -
Horská Alena,
Uluǧ Aziz M.,
Melhem Elias R.,
Filippi Christopher G.,
Burger Peter C.,
Edgar Mark A.,
Souweidane Mark M.,
Carson Benjamin S.,
Barker Peter B.
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1154
Subject(s) - choroid plexus , choroid plexus papilloma , choline , magnetic resonance imaging , medicine , creatine , choroid , pathology , proton magnetic resonance , nuclear medicine , nuclear magnetic resonance , radiology , central nervous system , biology , neuroscience , retina , physics
A variety of lesions may present as intraventricular masses in children. We report quantitative proton magnetic resonance spectroscopy (MRS) of two intraventricular tumors of the choroid plexus: choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP). Both lesions were characterized by high levels of choline‐containing compounds and a complete absence of creatine and the neuronal/axonal marker N‐acetyl aspartate. The CPC showed higher levels of choline compared to the CPP, and it also had elevated lactate. These preliminary results, if confirmed in a larger cohort of patients, indicate that proton MRS may have a role in the presurgical diagnosis of choroid plexus tumors in children, which may also have important implications for therapy and prognosis. J. Magn. Reson. Imaging 2001;14:78–82. © 2001 Wiley‐Liss, Inc.
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