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Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain
Author(s) -
Venkatesh Sudhakar K.,
Gupta Rakesh K.,
Pal Lily,
Husain Nuzhat,
Husain Mazhar
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1144
Subject(s) - pathology , histopathology , choline , granuloma , magnetic resonance imaging , in vivo , medicine , necrosis , biology , radiology , microbiology and biotechnology
We report in vivo proton magnetic resonance (MR) spectroscopic findings in three benign infective/inflammatory lesions (one case each of tuberculoma, fungal granuloma, and xanthogranuloma), which showed high choline along with the presence of lipid/lactate, a feature characteristically described in neoplastic lesions. Histopathology of the lesions showed inflammatory cellular infiltrates with areas of necrosis/caseation. The spectroscopic‐visible increased choline resonance in these lesions is probably the result of cellularity. We conclude that increased choline, along with the presence of lipid/lactate is a nonspecific finding and may not be of much value in the differentiation of neoplastic from nonneoplastic infective/inflammatory intracranial mass lesions. J. Magn. Reson. Imaging 2001;14:8–15. © 2001 Wiley‐Liss, Inc.