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Critical role of spatial resolution in dynamic contrast‐enhanced breast MRI
Author(s) -
FurmanHaran Edna,
Grobgeld Dov,
Kelcz Frederick,
Degani Hadassa
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1123
Subject(s) - image resolution , contrast (vision) , dynamic contrast , dynamic contrast enhanced mri , nuclear medicine , washout , resolution (logic) , gradient echo , high resolution , temporal resolution , breast mri , medical diagnosis , magnetic resonance imaging , radiology , medicine , computer science , breast cancer , artificial intelligence , optics , mammography , physics , geology , remote sensing , cancer
The spatial resolution of three‐dimensional (3D) gradient‐echo T1‐weighted images, from 40 women with 25 malignant and 23 benign lesions, was purposely degraded to determine the role of spatial resolution in recording, analysis, and diagnosis of dynamic contrast‐enhanced breast MRI. Images were recorded and analyzed at pixel resolution according to the 3TP method (Degani et al., Nat Med 1997;3:780–782). Reduction in spatial resolution degraded the appearance of foci with fast wash‐in and fast washout dynamics. This resulted in an increase in false‐negative diagnoses. The sensitivity for differentiating between malignant and benign lesions, using threshold criteria defined by the 3TP analysis, of 76% decreased to 60% and 24% for a 2‐ and 4‐fold reduction in spatial resolution, respectively, without affecting significantly the high specificity (96–100%). In order to minimize false‐negative diagnoses of contrast‐enhanced breast MRI and maintain high specificity, it is essential to record and analyze the dynamic behavior at high spatial resolution. J. Magn. Reson. Imaging 2001;13:862–867. © 2001 Wiley‐Liss, Inc.