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Fast 13 C‐glucose metabolite mapping in rat brain using 1 H echo planar spectroscopic imaging technique at 2T
Author(s) -
Morikawa Shigehiro,
Inubushi Toshiro
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1109
Subject(s) - nuclear magnetic resonance , metabolite , echo time , echo planar imaging , magnetic resonance spectroscopic imaging , chemistry , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , nuclear medicine , physics , medicine , radiology , biochemistry
For fast 13 C metabolite mapping in rat brains, 1 H‐detected 13 C NMR spectroscopy using gradient‐enhanced heteronuclear multiple‐quantum coherence and 1 H echo planar spectroscopic imaging were combined. 13 C glucose and 3‐/4‐ 13 C‐Glu/Gln images of rat brain were successfully constructed with 35‐minute temporal resolution under a 2T magnetic field. In the ischemic region of the suture middle cerebral artery occlusion model, glucose and Glu/Gln signals decreased and lactate signals appeared. J. Magn. Reson. Imaging 2001;13:787–791. © 2001 Wiley‐Liss, Inc.