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Slow clearance gadolinium‐based extracellular and intravascular contrast media for three‐dimensional MR angiography
Author(s) -
Bremerich Jens,
Colet Jean Marie,
Giovenzana Giovanni Battista,
Aime Silvio,
Scheffler Klaus,
Laurent Sophie,
Bongartz Georg,
Muller Robert N.
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1082
Subject(s) - extracellular , gadobutrol , gadolinium , extracellular fluid , nuclear medicine , clearance , medicine , magnetic resonance imaging , perfusion , distribution (mathematics) , nuclear magnetic resonance , chemistry , radiology , urology , physics , mathematical analysis , biochemistry , mathematics , organic chemistry
The objective of this study was to assess two new slow‐clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd‐DTPA‐BC 2 glucA and intravascular Gd(DO3A) 3 ‐lys 16 were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD‐A2‐Gd‐DOTA and extracellular GdDOTA, in 12 rats. Pre‐ and post‐contrast three‐dimensional MR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm 3 ) was acquired for 2 hours. Signal‐to‐noise enhancement (ΔSNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The ΔSNR for Gd‐DTPA‐BC 2 glucA, Gd(DO3A) 3 ‐lys 16 , CMD‐A2‐Gd‐DOTA, and GdDOTA were 13.0 ± 1.8, 25.0 ± 3.2, 25.0 ± 4.0, and 18.0 ± 3.4, respectively. Gd‐DTPA‐BC 2 glucA, Gd(DO3A) 3 ‐lys 16 , and CMD‐A2‐Gd‐DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular ΔSNR at 2 hours were 2.9 ± 0.6, 25.0 ± 3.2, 25.0 ± 4.0, and 0.4 ± 1.0. Gd(DO3A) 3 ‐lys 16 provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd‐DTPA‐BC 2 glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability. J. Magn. Reson. Imaging 2001;13:588–593. © 2001 Wiley‐Liss, Inc.