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Myocardial flow reserve parametric map, assessed by first‐pass MRI compartmental analysis at the chronic stage of infarction
Author(s) -
Germain Philippe,
Roul Gérald,
Baruthio Joseph,
Jahn Christine,
Coulbois Paul M.,
Dumitresco Barbu,
Dietemann Jean L.,
Bareiss Pierre,
Constantinesco A.
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1050
Subject(s) - medicine , myocardial infarction , fractional flow reserve , cardiology , infarction , stage (stratigraphy) , nuclear medicine , blood flow , artery , coronary angiography , paleontology , biology
Regional myocardial flow and flow reserve (MFR) were assessed by compartmental analysis of Gd‐enhanced MRI first‐pass data in 7 patients with atypical chest pain, and in 15 patients with previous transmural myocardial infarction. The FE product (Flow × Extraction coefficient), derived from the modified Kety equation, was measured in regions corresponding to the Tetrofosmine‐SPECT fixed defect and in remote normal regions. The FE product at rest and hyperemic FE product were similar in healed revascularized tissues (70.5 ± 15.6 and 112.5 ± 19.5ml/mn/100g, respectively) and in normal myocardium (76.2 ± 18.3 and 142.2 ± 33.0, respectively). In contrast, the FE index (48.8 ± 15.2 and 60.7 ± 18.0, respectively, P < 0.01 versus the two previous groups) and the MFR (1.27 ± 0.20 vs. 1.91 ± 0.29 in normal regions) were reduced in healed fibrotic tissues when the infarct‐related artery remained occluded. Myocardial flow reserve maps allowed correct identification of regions corresponding to an occluded infarct‐related artery. J. Magn. Reson. Imaging 2001;13:352–360. © 2001 Wiley‐Liss, Inc.