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Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: A comparison of different patterns by magnetic resonance
Author(s) -
Rumpel Helmut,
Khoo James B. K.,
Chang Hui Meng,
Lim Winston E. H.,
Chen Christopher,
Wong Meng Cheong,
Tan Kim Ping
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1048
Subject(s) - effective diffusion coefficient , lesion , medicine , stroke (engine) , magnetic resonance imaging , creatine , nuclear medicine , voxel , diffusion mri , context (archaeology) , pathology , nuclear magnetic resonance , radiology , physics , biology , paleontology , thermodynamics
It has been reported that reduction of the apparent diffusion coefficient (ADC) after stroke can persist for several days, after which the ADC increases gradually to an abnormally high level. We evaluated ADC values of stroke lesions and compared the results to the cellular density of the lesion by means of the creatine (Cre) level. This two‐parameter estimation is of particular relevance in ascertaining the underlying cellular status. Lesion‐to‐contralateral ADC ratios (ADC n ) were obtained based on diffusion‐weighted echo‐planar and fast spin‐echo imaging. Single‐voxel localized spectroscopy was used for quantification of cerebral metabolites in infarcted regions. Their levels were also compared to that in homotopic contralateral regions. Fifteen patients with ischemic stroke were examined at times ranging from 18–88 hours following the onset of symptoms. In the stroke lesion, there was a significant correlation between the ADC and the Cre level showing that the higher the cell density the lower the ADC value. For ADC n vs. the lesion Cre concentration and the lesion‐to‐contralateral Cre ratio (Cre n ), the strengths of relationship were R 2 = 0.70 and 0.58, respectively. It is concluded that ADC is a good reflection of cell density. Greatly lowered ADC values occur within the context of a stable cellularity. ADC and the Cre level have complementary roles in the characterization of stroke lesion with regard to the sequential stage. J. Magn. Reson. Imaging 2001;13:335–343. © 2001 Wiley‐Liss, Inc.