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Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide‐enhanced T1‐weighted gradient‐echo MR images: Correlation between MR imaging and histopathologic findings
Author(s) -
Kanematsu Masayuki,
Matsuo Masayuki,
Yamada Yasuhiro,
Semelka Richard C.,
Kondo Hiroshi,
Goshima Satoshi,
Hoshi Hiroaki,
Moriyama Noriyuki
Publication year - 2003
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10328
Subject(s) - medicine , parenchyma , magnetic resonance imaging , infiltration (hvac) , pathology , gradient echo , nuclear medicine , radiology , physics , thermodynamics
Purpose To correlate the perilesional hyperintense rim of malignant hepatic tumors seen on ferumoxide‐enhanced T1‐weighted gradient‐echo (GE) MR images with histopathologic findings. Materials and Methods In 13 tumors in 12 patients, T1‐weighted GE images (TE of 1.4 msec, flip angle of 90 degrees) obtained after IV administration of ferumoxide were evaluated. MR imaging was initiated within one hour of the completion of ferumoxide administration. Surgical resection for tumors was performed within an interval of two weeks of the MR imaging. Resected specimens were histopathologically examined for peritumoral sinusoidal congestion, desmoplastic reaction, compressed hepatic parenchyma, lymphocytic infiltration, and vascular proliferation. Results In twelve tumors (92%), prominently ( N = 2), moderately ( N = 5), and mildly to minimally ( N = 5), a perilesional hyperintense rim was observed. Among histopathologic findings, the degree of peritumoral sinusoidal congestion correlated ( R = .75, P < .04) with the degree of perilesional hyperintense rim. The thickness of the perilesional hyperintense rim showed a moderate positive correlation ( R = .65, P < .02) with the thickness of peritumoral area with sinusoidal congestion. Conclusion Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide‐enhanced T1‐weighted GE images may correlate with sinusoidal congestion surrounding malignant hepatic tumors. J. Magn. Reson. Imaging 2003;18:40–48. © 2003 Wiley‐Liss, Inc.