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Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice
Author(s) -
Itskovich Vitalii V.,
Lieb Mark,
Aguinaldo Juan Gilberto S.,
Samber Daniel D.,
Ramirez Francesco,
Fayad Zahi A.
Publication year - 2003
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10279
Subject(s) - marfan syndrome , magnetic resonance imaging , aorta , medicine , pathology , cardiology , radiology
Abstract Purpose To use noninvasive magnetic resonance microscopy (MRM) to examine aneurysmal disease in the mouse model of Marfan syndrome (MFS). Materials and Methods A total of eight wild‐type (WT) and MFS mice were imaged using MRM; four of them at three different time points over an 8‐week period and the remaining animals were imaged at one time point. The maximal cross‐sectional area of the aorta was measured by manual tracing and by automated means from combined cardiac and respiratory‐gated bright‐blood images. Relationships between aortic size and age and the differences between WT and mutant mice aortic size were established. Results Maximal cross‐sectional aortic areas differed significantly ( P < 0.05) between WT and mutant mice for all time points, with MFS mice having larger aortic size. There was a positive correlation between aortic size and age in MFS mice (r = 0.80) with a significant increase from the 14th to the 22nd week ( P < 0.05). Conclusion MRM detected the differences in aortic size between WT and mutant mice over time, demonstrating a potential for noninvasive technique for the assessment of potential therapies in MFS mice. J. Magn. Reson. Imaging 2003;17:435–439. © 2003 Wiley‐Liss, Inc.