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Investigating the stimulus‐dependent temporal dynamics of the BOLD signal using spectral methods
Author(s) -
Müller Karsten,
Mildner Toralf,
Lohmann Gabriele,
von Cramon D. Yves
Publication year - 2003
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10268
Subject(s) - stimulus (psychology) , dynamics (music) , spectral analysis , neuroscience , computer science , biological system , chemistry , physics , psychology , biology , cognitive psychology , acoustics , spectroscopy , quantum mechanics
Purpose To compare several spectral parameters using different durations of visual hemifield stimulation in order to explore the different temporal behavior of the blood oxygenation‐level dependent (BOLD) signal in various brain regions. Materials and Methods Spectral methods were applied to three different groups of subjects with visual stimulation lasting 6, 12, and 30 seconds. Furthermore, diffusion weighting was applied in an interleaved way. The core of the data processing was the computation of the spectral density matrix using the multidimensional weighted covariance estimate. Spectral parameters of coherence and phase shift were computed. Results The correlation between signal changes and phase shifts was dependent on the duration of the visual stimulation. The shorter the duration of visual stimulation, the stronger the correlation between percentage signal change and phase shift. Conclusion The experiments with short and long stimuli differed mainly in the distribution of the activated voxels in the plane of percentage signal change and phase shift. It was revealed that the height of the signal change depends on the phase shift, whereas the diffusion weighting has no influence. J. Magn. Reson. Imaging 2003;17:375–382. © 2003 Wiley‐Liss, Inc.