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In vivo and in vitro MR spectroscopic profile of central neurocytomas
Author(s) -
Jayasundar Rama,
Shah Tariq,
Vaishya Sandeep,
Singh Virender P.,
Sarkar Chitra
Publication year - 2003
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10252
Subject(s) - in vivo , nuclear magnetic resonance , in vitro , phosphocholine , choline , magnetic resonance imaging , in vivo magnetic resonance spectroscopy , chemistry , glycine , proton magnetic resonance , pathology , nuclear magnetic resonance spectroscopy , nuclear medicine , medicine , biology , biochemistry , phospholipid , radiology , amino acid , physics , phosphatidylcholine , microbiology and biotechnology , membrane
This study reports in vivo and in vitro magnetic resonance spectroscopic findings in two cases of central neurocytomas (CNC) confirmed by immunohistochemistry. Volume localized in vivo proton magnetic resonance spectroscopy (MRS) was carried out before surgery using a point resolved spectroscopy (PRESS) sequence with a repetition time of six seconds and an echo time of 135 msec. Normal spectrum was obtained from gray matter from a volunteer for comparison. 1 H and 31 P in vitro MRS studies were carried out at 9.4 T on the extracts prepared from the surgically excised tumors. The in vivo spectra showed prominent glycine (Gly) and choline (Cho) and low N‐acetyl aspartate compared to the normal. The Gly peak was assigned using the in vitro studies. These studies showed that the major contribution to the Cho peak observed in vivo is from phosphocholine. A combination of the presence of NAA and an increased Gly in the proton MR spectrum could be a characteristic feature of CNCs, which are rare intraventricular tumors of neuronal origin. J. Magn. Reson. Imaging 2003;17:256–260. © 2003 Wiley‐Liss, Inc.