Premium
Diffusion‐weighted MRI after cryosurgery of the canine prostate
Author(s) -
Butts Kim,
Daniel Bruce L.,
Chen Lili,
M. Bouley Donna,
Wansapura Janaka,
Maier Stephan E.,
Dumoulin Charles,
Watkins Ron
Publication year - 2003
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10227
Subject(s) - cryosurgery , effective diffusion coefficient , h&e stain , prostate , magnetic resonance imaging , staining , pathology , nuclear medicine , lesion , medicine , diffusion , nuclear magnetic resonance , anatomy , radiology , cancer , physics , thermodynamics
Purpose To evaluate the acute lesion created by cryosurgery with diffusion‐weighted magnetic resonance imaging (DWI). Materials and Methods The appearance of the acute cryolesion was evaluated in four canine prostates DWI after they were warmed to original body temperature. The prostates were excised, stained with triphenyl tetrazolium chloride (TTC), photographed, prepared for hematoxylin and eosin (H&E) staining, and examined under a light microscope. Results A marked decrease in apparent diffusion coefficient of 38% was evident in the center of the previously frozen tissue, but not in all of the previously frozen tissue. Histologic results confirm differences between the iceball core and the periphery of the iceball, which have markedly different imaging characteristics on DWI. Conclusion The core of the previously frozen tissue has a reduced apparent diffusion coefficient (ADC) compared to the periphery of the previously frozen tissue and previously unfrozen tissue. J. Magn. Reson. Imaging 2003;17:131–135. © 2002 Wiley‐Liss, Inc.