Premium
Development of an intravascular heating source using an MR imaging guidewire
Author(s) -
Qiu Bensheng,
Yeung Christopher J.,
Du Xiangying,
Atalar Ergin,
Yang Xiaoming
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10213
Subject(s) - materials science , balloon , microwave , biomedical engineering , magnetic resonance imaging , nuclear magnetic resonance , radiology , medicine , physics , quantum mechanics , cardiology
Purpose To develop a novel endovascular heating source using a magnetic resonance (MR) imaging guidewire (MRIG) to deliver controlled microwave energy into the target vessel for thermal enhancement of vascular gene transfection. Materials and Methods A 0.032‐inch MRIG was connected to a 2.45‐GHz microwave generator. We 1) calculated the microwave power loss along the MRIG, 2) simulated the power distribution around the MRIG, 3) measured the temperature increase vs. input power with the MRIG, and 4) evaluated the thermal effect on the balloon‐compressed/microwave‐heated aorta of six living rabbits. In addition, during balloon inflation, we also simultaneously generated high‐resolution MR images of the aortic wall. Results The power loss was calculated to be 3.9 dB along the MRIG. The simulation‐predicted power distribution pattern was cylindrically symmetric, analogous to the geometry of vessels. Under balloon compression, the vessel wall could be locally heated at 41°C with no thermal damage apparent on histology. Conclusion This study demonstrates the possibility of using the MRIG as a multifunctional device, not only as a receiver antenna to generate intravascular high‐resolution MR images of atherosclerotic plaques and as a conventional guidewire to guide endovascular interventions during MR imaging, but also as a potential intravascular heating source to produce local heat for thermal enhancement of vascular gene transfection. J. Magn. Reson. Imaging 2002;16:716–720. © 2002 Wiley‐Liss, Inc.