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1 H and 31 P spectroscopy and bioenergetics in the lateralization of seizures in temporal lobe epilepsy
Author(s) -
Hetherington Hoby P.,
Pan Jullie W.,
Spencer Dennis D.
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10177
Subject(s) - epilepsy , phosphocreatine , temporal lobe , bioenergetics , white matter , lateralization of brain function , pathophysiology , neuroscience , nuclear magnetic resonance , frontal lobe , chemistry , medicine , energy metabolism , mitochondrion , biology , magnetic resonance imaging , physics , biochemistry , radiology
Over the past decade, 1 H and 31 P spectroscopy measurements have demonstrated that significant metabolic alterations occur in temporal lobe epilepsy. However, to most accurately interpret these changes, metabolic heterogeneity and differences between gray and white matter must be accounted for. These alterations, decreased NAA and the ratio of phosphocreatine/inorganic phosphate, can be reversed with successful treatment of seizures. The reversibility of these two measures is consistent with the localization of NAA synthesis to neuronal mitochondria and the important role for bioenergetics in the pathophysiology of temporal lobe epilepsy. J. Magn. Reson. Imaging 2002;16:477–483. © 2002 Wiley‐Liss, Inc.