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FAIR and dynamic susceptibility contrast‐enhanced perfusion imaging in healthy subjects and stroke patients
Author(s) -
Hunsche Stefan,
Sauner Dieter,
Schreiber Wolfgang G.,
Oelkers Peter,
Stoeter Peter
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10150
Subject(s) - cerebral blood flow , perfusion , medicine , magnetic resonance imaging , perfusion scanning , white matter , contrast (vision) , cerebral blood volume , nuclear medicine , abnormality , stroke (engine) , cardiology , cerebral perfusion pressure , hemodynamics , radiology , mechanical engineering , artificial intelligence , psychiatry , computer science , engineering
Purpose To compare dynamic susceptibility contrast‐enhanced magnetic resonance imaging (DSC‐MRI) and the flow‐sensitive alternating inversion recovery (FAIR) technique for measuring brain perfusion. Materials and Methods We investigated 12 patients with acute stroke, and 10 healthy volunteers with FAIR and DSC maps of regional cerebral blood volume (rCBV), mean transit time (MTT), and regional cerebral blood flow (rCBF). Results In volunteers good gray/white‐matter contrast was observed in FAIR, rCBF, and rCBV maps. Regions with high signal intensities in FAIR matched well with high values of rCBV and rCBF. In ischemic stroke patients a high correlation (r = 0.78) of the ipsi‐ to contralateral signal intensity ratios in FAIR and rCBF was observed in areas with perfusion abnormalities. In contrast, FAIR and rCBV (r = 0.50), and FAIR and MTT (r = −0.22) correlated only modestly. Furthermore, FAIR and rCBF demonstrated similar sizes of perfusion abnormality. Conclusion This study demonstrates for the first time that FAIR and rCBF depict similar relations of perfusion in ischemic stroke patients and healthy subjects. J. Magn. Reson. Imaging 2002;16:137–146. © 2002 Wiley‐Liss, Inc.