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Time evolution of cerebral perfusion and apparent diffusion coefficient measured by magnetic resonance imaging in a porcine stroke model
Author(s) -
Røhl Lisbeth,
Sakoh Masaharuh,
Simonsen Claus Ziegler,
VestergaardPoulsen Peter,
Sangill Ryan,
Sørensen Jens Cristian,
Bjarkam Carsten Reidies,
Gyldensted Carsten,
Østergaard Leif
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10068
Subject(s) - medicine , putamen , magnetic resonance imaging , effective diffusion coefficient , stroke (engine) , diffusion mri , cerebral blood flow , perfusion , lesion , middle cerebral artery , nuclear medicine , perfusion scanning , cerebral cortex , cortex (anatomy) , radiology , ischemia , pathology , cardiology , neuroscience , psychology , mechanical engineering , engineering
Abstract Purpose To demonstrate the feasibility of sequential diffusion‐weighted (DW) and perfusion‐weighted (PW) magnetic resonance imaging (MRI) of a recently developed porcine stroke model and to evaluate the evolution of cerebral perfusion and the apparent diffusion coefficient (ADC) over time. Materials and Methods In five pigs, DW imaging (DWI) and PW imaging (PWI) was carried out for 7 hours after stroke onset, starting 1 hour after middle cerebral artery occlusion (MCAO). Results The DWI lesion volume increased significantly with time, and final DWI lesion volume correlated well with lesion area on histological sections (r = 0.910). T2 changes could be recognized 3 hours after stroke onset. At 1 hour the ADC ratio (ischemic lesion/contralateral side) was reduced to 0.81 in the caudate‐putamen and to 0.87 in the cortex, and the cerebral blood flow ratio was reduced to 0.40 in the caudate‐putamen and 0.51 in the cortex. Conclusion The level of flow reduction in the caudate‐putamen and the cortex after 1 hour is in good correlation with human thresholds of irreversible and reversible ischemic damage, and accordingly, this model might be a model for mechanisms of infarct evolution and therapeutic intervention. J. Magn. Reson. Imaging 2002;15:123–129. © 2002 Wiley‐Liss, Inc.