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MR imaging of diffuse adenomyosis changes after GnRH analog therapy
Author(s) -
Imaoka Izumi,
Ascher Susan M.,
Sugimura Kazuro,
Takahashi Kentaro,
Li Hong,
Cuomo Felicia,
Simon James,
Arnold Lori L.
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10060
Subject(s) - adenomyosis , medicine , myometrium , magnetic resonance imaging , nuclear medicine , radiology , uterus , endocrinology
Purpose To evaluate uterine changes on MRI before and after GnRH analog (GnRHa) treatment in diffuse adenomyosis. Materials and Methods Thirty‐one patients with MRI features suggestive of diffuse adenomyosis received GnRHa for 6 months. Diffuse adenomyosis was sub‐classified as: symmetric (symmetric/ entire widening of the junctional zone [JZ]) and asymmetric (asymmetric/ partial widening of JZ). Pre‐ and post‐high signal intensity (SI) foci and JZ width, and post‐demarcated change (interface of adenomyosis with the myometrium became more discrete with a concomitant decrease in JZ width) were analyzed. Results Before therapy, 15 of 18 asymmetric contained high SI foci compared to none of symmetric. After therapy, JZ width decreased ( P < 0.0001). Eight asymmetric and none of symmetric showed demarcated change with resolved high SI foci. Conclusion Our results suggest the use of GnRHa is associated with a decrease of JZ width in adenomyosis. Asymmetric adenomyosis with high SI foci appears to be the most sensitive to hormonal therapy. J. Magn. Reson. Imaging 2002;15:285–290. © 2002 Wiley‐Liss, Inc.